Platinum Metals Rev., 1991, 35, (3), 126
Homogeneous Palladium(II) Mediated Oxidation of Methane
Selective Functionalisation under Mild Conditions
A metal catalysed, electrophilic approach to methane oxidation is discussed. This involves the oxidation of methane to the corresponding methyl ester in trifluoroacetic acid; the oxidant is hydrogen peroxide and the catalyst is the palladium(II) ion. The latter species activates methane by the electrophilic cleavage of a C-H bond, and then acts as a two-electron oxidant towards the resultant metal-bound methyl group. The hydrogen peroxide reoxidises palladium(0) back to palladium(II)
Methane is the most abundant and the least reactive member of the hydrocarbon family. Thus, the selective functionalisation, preferably catalytic, of methane under mild conditions is one of the most challenging chemical problems, in addition to being of great practical importance. Among the various functionalisation possibilities, oxidative functionalisation is of special interest, since several commercially important organic chemicals (methanol, formaldehyde and formic acid) are nominally related to methane through oxidation steps.
The number of reported methods for the selective, low temperature (at about 100°C or below) functionalisation of methane is very limited indeed. For example, the radical initiated chlorination of methane is very nonselective and invariably leads to multiple chlorinations (1) (chlorination, however, is more specific in the presence of superacids (2)). Among transition metal mediated procedures, the only one that gives good yield involves catalysed oxidation of methane by in water at 120°C, which leads to the formation of equal amounts of methanol and methyl chloride (3).
The oxidative functionalisation of methane through direct reaction with molecular oxygen in homogeneous media at low to moderate temperatures is not a practical procedure for two principal reasons. The interaction of triplet oxygen with a singlet organic molecule is associated with a high activation energy barrier due to the requirement of a “spin-flip”. In addition, the auto-oxidation of alkanes is usually a chain reaction and is very non-specific in nature (4). In view of the above problems, it is attractive to consider metal mediated pathways for the oxidative functionalisation of methane. One role of the metal would be to stabilise unstable organic intermediates by binding to them. Specific reaction pathways may be promoted in this manner.
Sometimes, as shown in Equation (ii), an auxiliary ligand on the metal may assist in the le– oxidation step, as is observed with the enzyme cytochrome P450 (6, 7) and, perhaps, methane mono-oxygenases (8). Unfortunately, the methyl radical thus generated will participate in a multitude of reaction pathways. Only when severe steric restraints are present, as in an enzyme pocket, is any degree of specificity expected. In addition to the problem of reaction specificity, le– oxidation of methane is particularly unfavourable from a thermodynamic standpoint (see Table I) and, therefore, the generation of methyl radicals requires the use of rather strong oxidants and/or high temperatures (9).
|iso -C4H10||tert -C4,H9||–1.78|
The two common modes of interaction of a metal with methane that do not lead to the formation of radicals are oxidative addition, Equation (iii), and electrophilic displacement, Equation (iv). In recent years, Bergman, Graham and others have demonstrated that methane can participate in oxidative addition reactions (10).
However, a problem associated with this reaction is that the relative weakness of the metal-carbon bond often makes the oxidative addition step thermodynamically unfavourable (11). A common way to circumvent this problem is to generate a high-energy, co-ordinatively unsaturated species (usually by photochemical means) which then reacts, with the CH3-H bond in a “downhill” process. Unfortunately, the presence of the highly reactive metal species precludes the simultaneous presence of most oxidising reagents capable of functionalising the bound methyl group in the oxidative addition product. Thus, it is difficult to construct a “one pot” catalytic procedure for the oxidative functionalisation of methane that is based on Equation (iii).
The electrophilic displacement (heterolytic cleavage) pathway, Equation (iv) (3, 12, 13), is generally more favourable than the corresponding oxidative addition reaction for two reasons (11). First, the low reactivity of methane vis-a-vis most metal compounds is due, at least in part, to the absence of low-lying unoccupied orbitals. Hence, the transition state often involves the promotion of electrons into antibonding orbitals. Accordingly, the reactivity of methane is expected to be highest towards species having low-lying unoccupied orbitals, – that is to electrophiles. Second, the electrophilic displacement reaction is not as severely limited as is oxidative addition by the thermodynamic constraint associated with the weakness of the M-C bonds, since the driving force for processes such as Equation (iv) can be favourably influenced by the stabilisation of the leaving group, H+. For example, it has been shown that the analogous heterolytic cleavage of H2 by metal ions such as Cu2+, Ag+ and Hg2+ is favoured by the presence of bases which serve to stabilise the released H+ ion (14). Moreover, the recent reports of the addition of CH4 across a Zr = NR bond may be an example of base assisted heterolytic cleavage of an alkane C-H bond (15).
Our general scheme for oxidative functionalisation of methane is outlined in Equation (v) and is based on an initial electrophilic displacement step (12(a), (b)). The 2e– oxidant could be the metal itself or a separate reagent.
Ox = 2e– oxidant, Meox = oxidised organic product
If the metal acts both as the electrophile and oxidant, then the above scheme may be modified in the following way, Equation (vi). The overall reaction is shown in Equation (vii). If the final reduced metal species
Ox=2e– oxidant, Nu:– = nucleophile
can be reoxidised back (either chemically or electrochemically) then a catalytic cycle would ensue. Note that the steps involved in Equations (v) and (vi) are not totally unprecedented since Shilov and others have reported the following reaction sequence, Equation (viii) (3a). A comparison of Tables I and II also indicates that the 2e– oxidation of methane is significantly more favourable than the corresponding le– oxidation process.
|iso -C4H10||t -C4,H9OH||–0.31|
In the context of the reaction scheme depicted in Equation (vi), the Pd(II) ion is a particularly attractive choice for two reasons. First, as we and others have shown (16), the Pd(II) ion is a strong electrophile. For example, Pd(II) was found to activate olefins and small ring compounds through an initial electrophilic cleavage of the C-C π-bond or a C-C σ-a-bond, respectively, Equation (ix). In addition, as Table III illustrates (17), the electron affinity of Pd(II) is comparable to that of the traditional main-group Lewis acids.
|Ion||Promotion energy*,eV||Electron affinity, eV|
The second advantage in using Pd(II) is that it is a good 2e– oxidant (avoiding the formation of radicals). For example, the Pd(II) mediated 2e– oxidation of olefins and arenes is well-known (18). In addition, Pd metal can be readily oxidised back to Pd(II) using several different co-oxidants, such as Cu(II) + O2 and RONO, and this forms thebasis of several practical Pd(II) catalysed oxidation processes, such as, the Wacker process and the Pd(II) catalysed oxalate synthesis (19).
In our own work we chose to focus on the reactivity of the Pd(II) ion based on the arguments presented above (12). The initial problem involved the choice of the proper complex and the solvent, and Pd(II) in CF3CO2H was chosen for the following reasons: the CF3CO2– ion is a relatively poor base and M-O2CCF3 bonds are known to be quite labile (20). Therefore, the Pd(II) species present in the above system is expected to be labile and highly electrophilic. In this context, it is noteworthy that the electrophilic metallation of arenes by Tl(O2CCF3)3 occurs readily under mild conditions, while the corresponding acetate derivative is unreactive (21). Also of note is the observation of facile electrophilic cleavage of the allylic C-H bonds of olefins by Pd(O2CCF3)2 in CF3CO2H (22).
When CH4 (at 800 psi) was heated in the presence of Pd(O2CMe)2 in CF3CO2H at 80°C, a yield of approximately 60 per cent of CF3CO2Me together with precipitated Pd metal was observed, Equation (x) (12(a), (b)).
No deuterium incorporation into CF3CO2Me was observed when Pd(O2CCH3)2 was replaced by Pd(O2CCD3)2,
indicating that the MeCO2– group did not participate in the product formation through a decarboxylation step. Since the ester can be hydrolysed to the corresponding alcohol, the overall reaction can be written as follows:
Further information concerning the mechanism of the Pd(II) oxidation of hydrocarbons was obtained dirough the study of arene oxidations (12(a), (b)) which were also performed at 80°C using Pd(O2CMe)2 in CF3CO2H. Under these conditions, the monotri-fluoroacetoxylation of 1 equivalent of p- dimethoxybenzene proceeded to completion in 1 hour. Furthermore, comparative experiments indicated the following relative oxidation rates: p -dimethoxybenzene (1), p -xylene (0.1), toluene (0.02) and benzene (0). For p -xylene and toluene, attack on the ring rather than the benzylic position accounted for over 97 per cent and over 90 per cent, respectively, of the monotrifluoroacetate esters obtained. The two conclusions that can be drawn from our observations on Pd(II) oxidations (12(a), (b)) are that (a) radical pathways are not involved, since the weak benzylic C-H bonds were not attacked to any significant extent and (b) the enhanced rate of oxidation with electron-rich arenes is consistent with an electrophilic displacement pathway, as shown in Equations (iv) and (vi). The latter conclusion was further supported by the observation that the trifluoroacetoxylation of anisole proceeded to yield para and ortho products in a 3:1 ratio with almost no meta isomer formed.
In order to make the oxidation of methane catalytic in Pd(II), it is necessary to have a co-oxidant that is capable of reoxidising the Pd(0) formed at the end of the stoichiometric oxidation step, see Equation (vi). Hydrogen peroxide is one such co-oxidant. Thus, peroxytrifluoroacetic acid, generated from H2O2 and (CF3CO)2O, was found to oxidise methane specifically to CF2CO2Me, with the Pd(II) ion acting as the catalyst, see Figure 1(12c). The reaction shown in Equation (xi) can therefore be rewritten as follows:
The purpose of having an excess of trifluoroacetic anhydride is to remove the water generated, thereby preventing the hydrolysis of the ester to the more easily oxidised methanol. Ready further oxidation (eventually to CO2 and H2O) of the primary products is a persistent problem in the area of selective oxidation of alkanes. As is evident from Figure 1, our strategy works to a certain extent; however, at long reaction times, further oxidation of CF3CO2CH3 does occur. Significantly, this latter oxidation step is also catalysed by Pd(II) since CF3CO2CH3 was found to be stable in the reaction mixture in the absence of the metal.
The following observations seem to indicate that an electrophilic, rather than radical, mechanism also operates for the catalytic oxidation of methane. The oxidation of cis and trans 1,2-dimethylcyclohexane to the corresponding tertiary alcohols by peroxytrifluoroacetic acid was previously shown to proceed by complete retention of configuration (23). The addition of the Pd(II) ion to the system does not appear to alter the mechanism since, when p -xylene was used as the substrate, the ratio of esters derived from the attack on the ring versus the benzylic position was >100:1. Therefore, a radical pathway is not involved since the weak benzylic C-H bonds were not broken.
Since the catalytic cycle presumably combines the reaction shown in Equation (x), with a step involving the reoxidation of Pd(0) to Pd(II) by peroxytrifluoroacetic acid, it should be possible to initiate the catalytic cycle starting with Pd(0). The addition of “palladium black” to peroxytrifluoroacetic acid did result in an enhanced yield of CF3CO2CH3; nevertheless, the effect was much less than that observed with Pd(O2CC2H5)2, as shown in Figure 1. This observation does not necessarily rule out the above catalytic cycle since, in several catalytic oxidations involving the Pd(II)/(0)/(II) cycle, it has been observed that once Pd(0) is allowed to aggregate, it cannot be easily reoxidised to Pd(II) (24).
An alternative explanation for the catalytic effect of the Pd(II) ion encompasses attack by an incipient OH+ ion and proceeds through the following transition state (25). Under this
scenario, the Pd(II) ion promotes the reaction by coordination to the α-oxygen atom, thereby further polarising the O-O bond (26). Other metal ions should also have a similar effect. The substitution of Pd(O2CC2H5)2 by either Pb(O2CCH3)4, Fe(O2CCH3)2 or CO(O2C-CF3)2 however, (27) resulted in a yield of CF3CO2CH3 that is either similar to, or only marginally higher, than that observed with peroxytrifluoroacetic acid alone.
In conclusion, the selective transition metal catalysed, oxidation of methane through an electrophilic pathway under mild conditions has been demonstrated.
Note that the electrophilic oxidation of methane in superacid media is known (28). In the latter case, the methanol formed is protected from further oxidation by protonation to the methyloxonium ion.
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- 27 The oxidation of methane at elevated temperatures (∼180°C) by Co(0 2 CCF 3 ) 3 generated in situ has been reported: M. N. Vargaftik,, I. P. Stolarov and I. I. Moiseev, J. Chem. Soc, Chem. Commun., 1990, 1049 . However, this reagent appears to display little activity under the milder conditions that we have employed
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