Advanced Search
RSS LinkedIn Twitter

Journal Archive

Platinum Metals Rev., 1996, 40, (3), 127

Platinum Complexes Used in DNA Binding Studies

SHARE THIS PAGE:

DNA binding studies need unsaturated complexes with emissions sensitive to environmental changes to bind to DNA. Some ruthenium and platinum complexes have photoluminescence changes upon intercalation into calf-thymus (ct) DNA. Scientists at the University of Hong Kong, (H.-Q. Iiu, T.-C. Cheung and C.-M. Che, Chem. Commun., 1996, (9), 1039–1040) have now found two platinum complexes with dramatically enhanced photoluminescence on binding. [PfII(dpp-C,N,N’)(MeCN)]+ had a 271-fold increase in emission and had a 117-fold increase; dpp-C,N,N’ = C-depro-tonated 2,9-diphenyl-l,10-phenanthroline; pby-C,N,N’ = C-deprotonated 6-phenyl-2,2’-bipyri-dine and dppm = diphenylphosphinomethane. This is attributed to intercalation into et DNA, and may be used as luminescent switches for DNA.

BACK TO TOP

SHARE THIS PAGE: