Platinum Metals Rev., 1997, 41, (3), 141
Palladium Catalysts in Modern Organic Synthesis
Database of Palladium Chemistry: Reactions, Catalytic Cycles and Chemical Parameters CD-ROM version 1.0
Palladium mediated reactions are particularly valuable for the direct introduction of carbonyl groups, for forming carbon-carbon bonds via coupling processes typified by Heck reactions, and for selective oxidations such as those based on conventional Wacker reactions. Recent exciting results with asymmetric palladium-catalysed reactions will keep palladium at the forefront of new methodologies in synthetic organic chemistry. Therefore, many texts are available concerned with applications of palladium species in organic synthesis, such as those in (1, 2).
The present CDROM is not a text but a database of some 3500 published organic transformations in which ‘palladium’ is the catalyst. All the usual mechanistic types are represented and the records take the form of reference citations with equations showing structures of reactants and products, and other information. Author names, catalysts/ligands, structures, solvents, reactants and products can be searched, and this is a fairly rapid process. Substructures can be searched by using ISIS/Draw to draw the reaction, transferring it to the box “reaction”, then searching.
The database needs a PC with MS Windows 3.1 or later. The publishers suggest a Pentium processor with 16 MB of RAM and 20 MB of hard disk space if installation is to a hard drive; instructions are contained on the CDROM. Gaining familiarity with the database takes time, but the present reviewer did not find searching intuitive. The full database was not assessed as the review copy was a demonstration version.
However, there is certainly a place for such databases, but this one is not cheap. Potential users are probably already using on-line databases. So the price of a CDROM (and updates) has to be compared with on-line search costs. At present, this reviewer would tend to favour the latter, but as larger amounts of information become available at lower prices, the balance could move towards the use of CDROMs.
- 1J. Tsuji, “Palladium Reagents and Catalysts – Innovations in Organic Synthesis”, John Wiley & Sons, Chichester, 1995 ; see: Platinum Metals Rev ., 1996, 40, ( 3 ), 126
- 2H. M. Colquhoun,, D.J. Thompson and M.V. Twigg, “Carbonylation – Direct Synthesis of Carbonyl Compounds”, Plenum Press, New York, 1991