Johnson Matthey Technol. Rev., 2015, 59, (2), 120
Diego J. Ramón是西班牙坎特大学有机化学学院的一名教授。他的研究关注基于磁铁矿浸染的过渡金属氧化物的催化剂研发以及它们在有机化学领域一般用途的不同的反映中的应用。他已经发表了100多篇文章。
In the Lab: Ductile Metal Oxides Impregnated on Magnetite: New Catalysts in Organic Synthesis
Johnson Matthey Technology Review features new laboratory research
Diego J. Ramón is a Professor in the Department of Organic Chemistry at the University of Alicante, Spain. His research focuses on the development of catalysts based on transition metal oxides impregnated on the surface of magnetite and their application to different reactions of general interest in Organic Chemistry. He has published over 100 papers.
About the Researcher
Name: Diego J. Ramón
Department: Organic Chemistry
University: University of Alicante
Street: Carretera San Vicente del Raspeig s/n
Post Code: E-03080
Email Address: email@example.com
About the Research
The particle size of active material in heterogeneous catalysts has a great impact on selectivity, efficiency and specificity. In fact, nano-catalysts have properties different from the macroscopic systems due not only to different specific area but also to the presence of electric charges over them, and above all to the presence of extremely distorted bonds.
Metallic oxides, including magnesia, alumina, silica, zirconium oxide and cerium oxide, are supports commonly used in the preparation of nano-metal catalysts. Although magnetite (Fe3O4), like any other metal oxide, could be used as a suitable support, as has been demonstrated in other areas including medicine, biology and materials science, its use in organic chemistry has been minimal, due to the axiomatic idea that magnetite is unstable. As a support, magnetite has a unique advantage due to the superparamagnetic behaviour of its nanoparticles that allows its recovery and confinement by using a simple magnet or electromagnetic field. This property should make magnetite an ideal support material.
Ramón's group has designed a simple, robust and inexpensive methodology for the impregnation of different transition metal oxides on the surface of magnetite. The impregnation protocol allows all active nano-metallic species to be on the surface of the catalyst, and therefore increases their activity. The group has prepared catalysts derived from cobalt, copper, ruthenium, palladium, osmium, iridium and platinum (Figure 1). These versatile catalysts have been used to carry out several transformations of general interest in organic chemistry (Figure 2), among others Suzuki-Miyaura cross-coupling, the multicomponent reductive amination of aldehydes, hydrosilylation of alkynes, borylation of olefins, benzofurans and indole synthesis, and the alkylation of amines through a borrowing hydrogen strategy. Moreover it has been possible to achieve the first practical cross-alkylation of primary alcohols using iridium impregnated on magnetite.
When an external magnetic field is applied, the superparamagnetic particles of the magnetite acquire magnetisation, but it is lost when the magnetic field is retired. So, magnetite nanoparticles can be isolated easily from the reaction media using an external magnet (Figure 3) after the reaction. In many cases, the catalyst could be recovered by the simple use of a magnet and recycled in successive cycles with the same initial activity. Figure 4 shows the yields obtained with the different catalysts in ten successive reaction cycles.
- J. M. Pérez and D. J. Ramón, Adv. Synth. Catal., 2014, 356, (14–15), 3039 LINK http://dx.doi.org/10.1002/adsc.201400207
- J. M. Pérez, R. Cano and D. J. Ramón, RSC Adv., 2014, 4, (46), 23943 LINK http://dx.doi.org/10.1039/C4RA03149K
- R. Cano, J. M. Pérez and D. J. Ramón, Appl. Catal. A: Gen., 2014, 470, 177 LINK http://dx.doi.org/10.1016/j.apcata.2013.10.050
- R. Cano, M. Yus and D. J. Ramón, Tetrahedron, 2013, 69, (34), 7056 LINK http://dx.doi.org/10.1016/j.tet.2013.06.041
- J. M. Pérez, R. Cano, M. Yus and D. J. Ramón, Synthesis, 2013, 45, (10), 1373 LINK http://dx.doi.org/10.1055/s-0032-1316872
- J. M. Pérez, R. Cano, M. Yus and D. J. Ramón, Eur. J. Org. Chem., 2012, (24), 4548 LINK http://dx.doi.org/10.1002/ejoc.201200319
- R. Cano, M. Yus and D. J. Ramón, Chem. Commun., 2012, 48, (61), 7628 LINK http://dx.doi.org/10.1039/c2cc33101b
- R. Cano, M. Yus and D. J. Ramón, ACS Catal., 2012, 2, (6), 1070 LINK http://dx.doi.org/10.1021/cs300056e
- R. Cano, M. Yus and D. J. Ramón, Tetrahedron, 2012, 68, (5), 1393 LINK http://dx.doi.org/10.1016/j.tet.2011.12.042
- R. Cano, M. Yus and D. J. Ramón, Tetrahedron, 2011, 67, (42), 8079 LINK http://dx.doi.org/10.1016/j.tet.2011.08.063
- R. Cano, D. J. Ramón and M. Yus, Synlett, 2011, (14), 2017 LINK http://dx.doi.org/10.1055/s-0030-1261162
- R. Cano, D. J. Ramón and M. Yus, J. Org. Chem., 2011, 76, (14), 5547 LINK http://dx.doi.org/10.1021/jo200559h
- R. Cano, D. J. Ramón and M. Yus, Tetrahedron, 2011, 67, (30), 5432 LINK http://dx.doi.org/10.1016/j.tet.2011.05.072
- R. Cano, D. J. Ramón and M. Yus, J. Org. Chem., 2010, 75, (10), 3458 LINK http://dx.doi.org/10.1021/jo100325e
- M. J. Aliaga, D. J. Ramón and M. Yus, Org. Biomol. Chem., 2010, 8, (1), 43 LINK http://dx.doi.org/10.1039/b917923b
- R. Martínez, D. J. Ramón and M. Yus, Adv. Synth. Catal., 2008, 350, (9), 1235 LINK http://dx.doi.org/10.1002/adsc.200800089